The Ameliorating Effect of Lizhong-Tang on Antibiotic-Associated Imbalance in the Gut Microbiota in Mouseopen access
- Authors
- Ahn, Hye-Ri; Park, Do Hwi; Shin, Myoung-Sook; Nguyen, Quynh Nhu; Park, Jun Yeon; Kim, Dong-Wook; Kang, Ki Sung; Lee, Hye Lim
- Issue Date
- Jul-2022
- Publisher
- MDPI
- Keywords
- herbal medicine; Lizhong-tang; gut microbiota; anti-inflammatory
- Citation
- APPLIED SCIENCES-BASEL, v.12, no.14
- Journal Title
- APPLIED SCIENCES-BASEL
- Volume
- 12
- Number
- 14
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85537
- DOI
- 10.3390/app12146943
- ISSN
- 2076-3417
- Abstract
- Some herbal medicines have anti-inflammatory and anti-diarrheal effects. This study analyzed the modulating effect of gut microbiota of anti-inflammatory herbal medicines on antibiotic-associated diarrhea (AAD). The anti-inflammatory effects of 10 herbal medicines and Lizhong-tang active compounds were studied by measuring the nitric oxide production in an in vitro experiment. This was followed by an in vivo experiment in which the anti-diarrheal effects of Lizhong-tang and Magnolia officinalis in a lincomycin-induced AAD mouse model were measured. Changes in the intestinal microflora were observed using terminal restriction fragment length polymorphism analysis. Both Lizhong-tang and M. officinalis were effective against AAD, with Lizhong-tang's anti-diarrheal effects being particularly effective. In addition, the active compounds of Lizhong-tang, liquiritin and 6-gingerol, inhibited the expression of inducible nitric oxide synthase and cyclooxygenase-2, thus showing an anti-inflammatory effect. Gut microbiota analysis showed that Lizhong-tang could alter the composition of the gut microbiota and ameliorated imbalance in the gut microbiota in a lincomycin-induced AAD mouse model.
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