가시오가피 열매 추출물이 유방암 세포주에 미치는 영향Effect of Extract of Acanthopanax Senticosus Fruit on Breast Cancer Cells
- Other Titles
- Effect of Extract of Acanthopanax Senticosus Fruit on Breast Cancer Cells
- Authors
- 황종현; 김승만; 황귀서; 전찬용; 강기성
- Issue Date
- Sep-2022
- Publisher
- 대한한방내과학회
- Keywords
- Acanthopanax senticosus; breast cancer; MCF-7; MDA-MB-231
- Citation
- 대한한방내과학회지, v.43, no.4, pp.529 - 541
- Journal Title
- 대한한방내과학회지
- Volume
- 43
- Number
- 4
- Start Page
- 529
- End Page
- 541
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85810
- DOI
- 10.22246/jikm.2022.43.4.529
- ISSN
- 1226-9174
- Abstract
- Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231).
Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR.
Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line.
Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death.
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