Comparison of the antiviral activity of flavonoids against murine norovirus and feline calicivirus
- Authors
- Seo, Dong Joo; Jeon, Su Been; Oh, Hyejin; Lee, Bog-Hieu; Lee, Sook-Young; Oh, Seung Hyun; Jung, Ji Youn; Choi, Changsun
- Issue Date
- Feb-2016
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Norovirus; Flavonoid; Antiviral; Structure-activity relationship (SAR); Feline calicivirus (FCV)
- Citation
- FOOD CONTROL, v.60, pp.25 - 30
- Journal Title
- FOOD CONTROL
- Volume
- 60
- Start Page
- 25
- End Page
- 30
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8581
- DOI
- 10.1016/j.foodcont.2015.07.023
- ISSN
- 0956-7135
- Abstract
- Antiviral effect of 10 flavonoids against feline calicivirus (FCV) and murine norovirus (MNV) was investigated on Crandell-Reese feline kidney (CRFK) cells and RAW 264.7 cells. Each cells infected with FCV or MNV was treated with different flavonoids at concentrations between 50 and 300 mu M. A 200 mu M dose of kaempferol and daidzein significantly reduced the FCV titer by 69.76 +/- 8.71 and 63.47 +/- 9.82%, respectively. A 300 mu M dose of quercetin and fisetin reduced the titer of FCV titer by 56.70 +/- 11.39 and 41.84 +/- 11.35%, respectively. The titer of MNV was reduced by 50.47 +/- 6.91 and 51.21 +/- 13.38% by a 50 mu M dose of fisetin or a 150 mu M dose of epicatechin gallate, respectively. A 50 mu M dose of daidzein and 100 mu M of quercetin reduced the MNV titer by 46.32 +/- 8.70 and 45.78 +/- 9.81%, respectively. The pre-treatment of quercetin, fisetin, daidzein, and epicatechin gallate demonstrated the anti-noroviral activity against MNV and FCV. (C) 2015 Elsevier Ltd. All rights reserved.
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