Astaxanthin Ameliorates Atopic Dermatitis by Inhibiting the Expression of Signal Molecule NF-kB and Inflammatory Genes in Miceopen access
- Authors
- Kim, Donghwan; Kim, Yong-Suk; Song, Ho Sueb
- Issue Date
- Nov-2022
- Publisher
- 대한침구의학회
- Keywords
- astaxanthin; atopic dermatitis; inflammation; NF-kB
- Citation
- Journal of Acupuncture Research, v.39, no.4, pp.304 - 309
- Journal Title
- Journal of Acupuncture Research
- Volume
- 39
- Number
- 4
- Start Page
- 304
- End Page
- 309
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86183
- DOI
- 10.13045/jar.2022.00255
- ISSN
- 2586-288X
- Abstract
- Background: This study was conducted to determine the anti-inflammatory effect of astaxanthin, on atopic dermatitis.Methods: Changes in mouse body weight, lymph node weight, and the degree of improvement in symptoms were measured to determine the inflammatory response. Real-time reverse transcription-polymerase chain reaction tests were performed to determine the degree of expression of inflammation-related cytokines (IL-31 and IL-33 and chemokines such as CCL17 and CCL22), and western blot analysis was performed to evaluate the expression of inflammation-related factors (iNOS, COX-2, and NF-kB signaling molecules p-IkBα, p50, p-65 and pSTAT3).Results: The degree of symptoms significantly improved in the PA+AX group. Lymph node weight in the PA+AX group was lower than the PA group. Inflammatory cytokines (IL-31, IL-33, and inflammatory chemokines such as CCL17 and CCL22) were significantly reduced in the PA+AX group compared with the PA group. The expression of inflammatory genes (iNOS, COX-2, NF-kB and signaling molecules (p-IkBα, p50, p65, and p-STAT 3) was lower in the PA+AX group compared with the PA group.Conclusion: Astaxanthin may modulate the inflammatory response in a mouse model of atopic dermatitis and has an anti-inflammatory effect.
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