Safety of using Escherichia coli bacteriophages as a sanitizing agent based on inflammatory responses in rats
- Authors
- Hwang, Ji-Yeon; Kim, Jung-Eun; Song, Yoon-Jae; Park, Jong-Hyun
- Issue Date
- Feb-2016
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- E. coli bacteriophage; pro-inflammatory cytokine; phage-fed rat
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.25, no.1, pp.355 - 360
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 25
- Number
- 1
- Start Page
- 355
- End Page
- 360
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8634
- DOI
- 10.1007/s10068-016-0050-6
- ISSN
- 1226-7708
- Abstract
- Use of bacteriophages as sanitizing agents has received much attention. However, safety in humans is debatable. To determine inflammatory immune responses against bacteriophages, rats were treated with a 8 log plaque-forming cocktail of 5 bacteriophages for pathogenic Escherichia coli per day for 4 weeks. Food consumption, feeding efficiency, and body weight of rats treated with the cocktail were not different from controls. Phages were not detected in the sera of phage-fed rats with no changes in organ weights. Notable changes were not observed upon histopathological examination of the liver, kidney, and spleen. Pro-inflammatory cytokine mRNA expression, except COX-2 (2.4x increase), remained unaffected after treatment with the phage cocktail. No remarkable changes were observed for levels of 12 pro-inflammatory cytokines in sera. Inflammatory responses in rats orally treated with a phage cocktail were not observed. Bacteriophages for E. coli are indicated as immunologically safe in rats.
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- 바이오나노대학 > 생명과학과 > 1. Journal Articles
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