Preparation of particle-attached microneedles using a dry coating process
- Authors
- Choi, Jeong-Eun; Cha, Hye-Ran; Kim, Suwan; Kim, Ji Seok; Kim, Mun-Jin; Chung, Hyeon Woo; Baek, Seung-Ki; Lee, Jae Myun; Park, Jung-Hwan
- Issue Date
- Nov-2022
- Publisher
- ELSEVIER
- Keywords
- Particle-attached microneedles; Physical attachment; Polydimethylsiloxane; Dry coating; Rapid delivery
- Citation
- JOURNAL OF CONTROLLED RELEASE, v.351, pp.1003 - 1016
- Journal Title
- JOURNAL OF CONTROLLED RELEASE
- Volume
- 351
- Start Page
- 1003
- End Page
- 1016
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86422
- DOI
- 10.1016/j.jconrel.2022.10.003
- ISSN
- 0168-3659
- Abstract
- The standard process for manufacturing microneedles containing API requires a way to process the API, including dissolving the API in a co-solvent and a drying process. In this study, the authors introduce a novel microneedle system that involves physically attaching API particles to the biocompatible adhesive surface of the microneedles. To manufacture particle-attached microneedles, an adhesive surface was prepared by coating polydimethylsiloxane (PDMS) mixed with an elastomer base and a curing agent at a ratio of 40:1 (PDMS40) onto polylactic acid microneedles (PLA), and then attaching ovalbumin (OVA) particles with a mean diameter of 10 mu m to the PDMS adhesive layer. The OVA particles were delivered for 5 min into porcine skin with a delivery efficiency of 93% ex vivo and into mouse skin with a delivery efficiency of over 90% in vivo. Finally, mouse experiments with OVA particle-attached microneedles showed a value of OVA antibody titer similar to that produced by intramuscular administration. Particle-attached microneedles are a novel microneedle system with a dry coating process and rapid API delivery into the skin. Particle-attached microneedles can provide a wide range of applications for administering drugs and vaccines.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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