Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities
- Authors
- Kim, Chung Sub; Subedi, Lalita; Kim, Sun Yeou; Choi, Sang Un; Kim, Ki Hyun; Lee, Kang Ro
- Issue Date
- Feb-2016
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.79, no.2, pp.387 - 394
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 79
- Number
- 2
- Start Page
- 387
- End Page
- 394
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8644
- DOI
- 10.1021/acs.jnatprod.5b01053
- ISSN
- 0163-3864
- Abstract
- Eleven new abietane-type diterpenes, holophyllins D-N (1-11), and 17 known analogues (12-28), were isolated from a MeOH extract of the trunk of Abies holophylla. The chemical structures of 1-11 were determined through spectroscopic data analysis, including NMR (H-1 and C-13 NMR, DEPT, H-1-H-1 COSY, HMQC, HMBC, and NOESY) and HRFABMS methods. All isolated compounds (1-28) were evaluated for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116), for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, and for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells.
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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