Mechanistic Insights into the Neuroprotective Potential of Sacred Ficus Treesopen access
- Authors
- Shim, Kyu Hwan; Sharma, Niti; An, Seong Soo A.
- Issue Date
- Nov-2022
- Publisher
- MDPI
- Keywords
- F; religiosa; F; benghalensis; neurodegenerative disorders; bioactive compounds; multi-target approach
- Citation
- NUTRIENTS, v.14, no.22
- Journal Title
- NUTRIENTS
- Volume
- 14
- Number
- 22
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86628
- DOI
- 10.3390/nu14224731
- ISSN
- 2072-6643
- Abstract
- Ficus religiosa (Bo tree or sacred fig) and Ficus benghalensis (Indian banyan) are of immense spiritual and therapeutic importance. Various parts of these trees have been investigated for their antioxidant, antimicrobial, anticonvulsant, antidiabetic, anti-inflammatory, analgesic, hepatoprotective, dermoprotective, and nephroprotective properties. Previous reviews of Ficus mostly discussed traditional usages, photochemistry, and pharmacological activities, though comprehensive reviews of the neuroprotective potential of these Ficus species extracts and/or their important phytocompounds are lacking. The interesting phytocompounds from these trees include many bengalenosides, carotenoids, flavonoids (leucopelargonidin-3-O-beta-d-glucopyranoside, leucopelargonidin-3-O-alpha-l-rhamnopyranoside, lupeol, cetyl behenate, and alpha-amyrin acetate), flavonols (kaempferol, quercetin, myricetin), leucocyanidin, phytosterols (bergapten, bergaptol, lanosterol, beta-sitosterol, stigmasterol), terpenes (alpha-thujene, alpha-pinene, beta-pinene, alpha-terpinene, limonene, beta-ocimene, beta-bourbonene, beta-caryophyllene, alpha-trans-bergamotene, alpha-copaene, aromadendrene, alpha-humulene, alloaromadendrene, germacrene, gamma-cadinene, and delta-cadinene), and diverse polyphenols (tannin, wax, saponin, leucoanthocyanin), contributing significantly to their pharmacological effects, ranging from antimicrobial action to neuroprotection. This review presents extensive mechanistic insights into the neuroprotective potential, especially important phytochemicals from F. religiosa and F. benghalensis. Owing to the complex pathophysiology of neurodegenerative disorders (NDDs), the currently existing drugs merely alleviate the symptoms. Hence, bioactive compounds with potent neuroprotective effects through a multitarget approach would be of great interest in developing pharmacophores for the treatment of NDDs.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86628)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.