Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Deliveryopen access
- Authors
- Zhang, Wei-Jin; Li, Shuwei; Yan, Yong-Zhu; Park, Sung Soo; Mohan, Anandhu; Chung, Ildoo; Ahn, Suk-kyun; Kim, Jung Rae; Ha, Chang-Sik
- Issue Date
- Dec-2022
- Publisher
- MDPI
- Keywords
- MXene; ROS-responsive; pH-responsive; antibacterial activity; doxorubicin; drug delivery
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.23
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 23
- Number
- 23
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86685
- DOI
- 10.3390/ijms232314925
- ISSN
- 1661-6596
- Abstract
- In this study, a novel MXene (Ti3C2Tx)-based nanocarrier was developed for drug delivery. MXene nanosheets were functionalized with 3, 3 '-diselanediyldipropionic acid (DSeDPA), followed by grafting doxorubicin (DOX) as a model drug to the surface of functionalized MXene nanosheets (MXene-Se-DOX). The nanosheets were characterized using scanning electron microscopy, atomic force microscopy (AFM), transmission electron microscopy, energy-dispersive X-ray spectroscopy (EDX), nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and zeta potential techniques. The drug-loading capacity (17.95%) and encapsulation efficiency (41.66%) were determined using ultraviolet-visible spectroscopy. The lateral size and thickness of the MXene nanosheets measured using AFM were 200 nm and 1.5 nm, respectively. The drug release behavior of the MXene-Se-DOX nanosheets was evaluated under different medium conditions, and the nanosheets demonstrated outstanding dual (reactive oxygen species (ROS)- and pH-) responsive properties. Furthermore, the MXene-Se-DOX nanosheets exhibited excellent antibacterial activity against both Gram-negative E. coli and Gram-positive B. subtilis.
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Collections - 산업·환경대학원 > 산업환경공학과 > 1. Journal Articles
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