Immunostimulatory Activity of Cordyceps militaris Fermented with Pediococcus pentosaceus SC11 Isolated from a Salted Small Octopus in Cyclophosphamide-Induced Immunocompromised Mice and Its Inhibitory Activity against SARS-CoV 3CL Proteaseopen access
- Authors
- Dhong, Kyu-Ree; Kwon, Ha-Kyoung; Park, Hye-Jin
- Issue Date
- Dec-2022
- Publisher
- MDPI
- Keywords
- Cordyceps militaris grown on germinated Rhychosia nulubilis fermented with Pediococcus pentosaceus SC11 (GRC-SC11); immune stimulatory; cyclophosphamide; SARS-CoV 3CL protease; splenocyte proliferation; macrophage; phagocytic activity
- Citation
- MICROORGANISMS, v.10, no.12
- Journal Title
- MICROORGANISMS
- Volume
- 10
- Number
- 12
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86714
- DOI
- 10.3390/microorganisms10122321
- ISSN
- 2076-2607
- Abstract
- In this study, we investigated the immune-enhancing and anti-viral effects of germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus SC11 (GRC-SC11) isolated from a salted small octopus. The cordycepin, beta-glucan, and total flavonoid contents increased in GRC after SC11 fermentation. GRC-SC11 inhibits 3CL protease activity in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). GRC-SC11 significantly increased thymus and spleen indices in immunocompromised mice. The rate of splenocyte proliferation was higher in GRC-SC11-treated immunocompromised mice than that in GRC-treated immunocompromised mice in the presence or absence of concanavalin A. In addition, GRC-SC11 increased the phagocytic activity and nitric oxide production in immunocompromised mice. The mRNA expression of interferon-gamma (IFN-gamma), interferon-alpha (IFN-alpha), and interferon-stimulated gene 15 (ISG15) was up-regulated in GRC-SC11 treated RAW 264.7 macrophages, compared to GRC. Our study indicates that GRC-SC11 might be a potential therapeutic agent for immunocompromised patients who are vulnerable to SARS-CoV infection.
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