Interlinking brain mapping and Parkinson’s disease: MRI analysis, nigrosome 1 and nigrosome 4
- Authors
- Kim, Eung Yeop; Sung, Young Hee; Lee, Jongho
- Issue Date
- Oct-2020
- Publisher
- Elsevier
- Keywords
- Dopamine transporter imaging; Magnetic resonance imaging; Neuromelanin-sensitive imaging; Nigrosome; Quantitative susceptibility mapping; Substantia nigra
- Citation
- Genetics, Neurology, Behavior, and Diet in Parkinson’s Disease: The Neuroscience of Parkinson’s Disease, Volume 2, pp.267 - 281
- Journal Title
- Genetics, Neurology, Behavior, and Diet in Parkinson’s Disease: The Neuroscience of Parkinson’s Disease, Volume 2
- Start Page
- 267
- End Page
- 281
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86866
- DOI
- 10.1016/B978-0-12-815950-7.00017-5
- ISSN
- 0000-0000
- Abstract
- The nigrosome 1 and 4 regions in the substantia nigra can be assessed separately by using high-spatial-resolution susceptibility map-weighted imaging. The nigrosome 1 region is mainly identified below the red nucleus, while the nigrosome 4 region is located at the level of the lower portion of the red nucleus on coronal-reformatted susceptibility map-weighted imaging. Each region exhibits differential involvement according to clinical stages in idiopathic Parkinson’s disease, with the nigrosome 1 region involved earlier, followed by the nigrosome 4 region. Such observations may be supported by coregistered high-spatial-resolution neuromelanin-sensitive imaging and the relationship with the extent of abnormality of dopamine transporter activity. From our results, we suggest that high-spatial-resolution susceptibility map-weighted imaging may serve not only as a diagnostic tool but also as an imaging biomarker for disease severity in idiopathic Parkinson’s disease. © 2020 Elsevier Inc.
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