Current and emerging applications of nanostructured metal organic frameworks in cancer-targeted theranostics
- Authors
- Lakshmi, Buddolla Anantha; Kim, Sanghyo
- Issue Date
- Dec-2019
- Publisher
- ELSEVIER
- Keywords
- Nanostructured metal organic frameworks; Cancer-targeted therapy; Photosensitization; Drug delivery
- Citation
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.105
- Journal Title
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
- Volume
- 105
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/869
- DOI
- 10.1016/j.msec.2019.110091
- ISSN
- 0928-4931
- Abstract
- Nanostructured metal-organic frameworks (N-MOFs) are crystalline coordination nanopolymers in which metals are conjugated with organic and inorganic linker molecules. At present, N-MOFs have attracted significant interest owing to their intrinsically high porosity and ultrahigh surface areas, which allow them to be loaded with a broad array of materials, including drug molecules. In addition, N-MOFs possess other unique properties, such as good mobility, high reactivity, outstanding stability, real-time intracellular pH sensitivity, photosensitization, and penetration ability, which make them suitable candidates as drug delivery carriers for cancer and other targeted therapies. The opportunity for using a diverse array of chemical building components in N-MOFs facilitates the formation of structures with preferred properties for targeted therapy. In this review, we focus on the synthesis, characterization and other potential applications of N-MOFs in targeted theranostic nanodrug for cancer therapy.
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