Alzheimer's disease-like cortical atrophy mediates the effect of air pollution on global cognitive functionopen access
- Authors
- Cho, Jaelim; Jang, Heeseon; Park, Hyunji; Noh, Young; Sohn, Jungwoo; Koh, Sang-Baek; Lee, Seung-Koo; Kim, Sun-Young; Kim, Changsoo
- Issue Date
- Jan-2023
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Epidemiology; Air pollution; Alzheimer?s disease; Cortical atrophy; Cognitive function; Mediation analysis
- Citation
- ENVIRONMENT INTERNATIONAL, v.171
- Journal Title
- ENVIRONMENT INTERNATIONAL
- Volume
- 171
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86923
- DOI
- 10.1016/j.envint.2022.107703
- ISSN
- 0160-4120
- Abstract
- Little is known about the effect of air pollution on Alzheimer's disease (AD)-specific brain structural pathologies. There is also a lack of evidence on whether this effect leads to poorer cognitive function. We investigated whether, and the extent to which, AD-like cortical atrophy mediated the association between air pollution exposures and cognitive function in dementia-free adults. We used cross-sectional data from 640 participants who underwent brain magnetic resonance imaging and the Montreal Cognitive Assessment (MoCA). Mean cortical thickness (as the measure of global cortical atrophy) and machine learning-based AD-like cortical atrophy score were estimated from brain images. Concentrations of particulate matter with diameters < 10 mu m (PM10) and < 2.5 mu m (PM2.5) and nitrogen dioxide (NO2) were estimated based on each participant's residential address. Following the product method, a mediation effect was tested by conducting a series of three regression analyses (exposure to outcome; exposure to mediator; and exposure and mediator to outcome). A 10 mu g/m3 increase in PM10 (13 =-1.13; 95 % CI,-1.73 to-0.53) and a 10 ppb increase in NO2 (13 =-1.09; 95 % CI,-1.40 to-0.78) were significantly associated with a lower MoCA score. PM10 (13 = 0.27; 95 % CI, 0.06 to 0.48) and NO2 (13 = 0.35; 95 % CI, 0.25 to 0.45) were significantly associated with an increased AD-like cortical atrophy score. Effects of PM10 and NO2 on MoCA scores were significantly mediated by mean cortical thickness (proportions mediated: 25 %-28 %) and AD-like cortical atrophy scores (13 %-16 %). The findings suggest that air pollution exposures may induce AD-like cortical atrophy, and that this effect may lead to poorer cognitive function in dementia-free adults.
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