(1' S)-1'-Acetoxyeugenol Acetate Enhances Glucose-Stimulated Insulin Secretionopen access
- Authors
- Lee, Dahae; Son, So-Ri; Qi, Yutong; Kang, Ki Sung; Jang, Dae Sik
- Issue Date
- Feb-2023
- Publisher
- MDPI
- Keywords
- Alpinia galanga; (1' S)-1' -acetoxyeugenol acetate; Insulin; alpha-glucosidase; PDX-1
- Citation
- PLANTS-BASEL, v.12, no.3
- Journal Title
- PLANTS-BASEL
- Volume
- 12
- Number
- 3
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87107
- DOI
- 10.3390/plants12030579
- ISSN
- 2223-7747
- Abstract
- Alpinia galanga have been widely used as spice or traditional medicine in East Asia, commonly known as Thai ginger. In the present study, seven major phenylpropanoids, (+/-)-1 '-hydoxychavicol acetate (1; HCA), (1 ' S)-1 '-acetoxychavicol acetate (2; ACA), (1 ' S)-1 '-acetoxyeugenol acetate (3; AEA), eugenyl acetate (4), trans-p-coumaraldehyde (5), trans-p-acetoxycinnamyl alcohol (6), and trans-p-coumaryl diacetate (7), were isolated from the 95% EtOH and hot water extracts of the rhizomes of A. galanga by chromatographic method. Phenylpropanoids 1-7 were evaluated for glucose-stimulated insulin secretion (GSIS) effect and oc-glucosidase inhibitory activity.Phenylpropanoids 1-4 increase GSIS effect without cytotoxicity in rat INS-1 pancreatic beta-cells. In addition, INS-1 cells were treated with AEA (3) to determine a plausible mechanism of beta-cell function and insulin secretion through determining the activation of insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and pancreatic and duodenal homeobox-1 (PDX-1). Upon treatment with AEA (3), INS-1 cells showed an increase in these protein expressions. Meanwhile, AEA (3) exhibited oc-glucosidase inhibitory activity. On the basis of the above findings, we suggest AEA (3) as a potential antidiabetic agent.
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