Home-Based Physical Activity and Diet Intervention to Improve Physical Function in Advanced Liver Disease: A Randomized Pilot Trial
- Authors
- Chen, Hui Wei; Ferrando, Arny; White, Michelle G.; Dennis, Richard A.; Xie, Jesse; Pauly, Margaret; Park, Sanghee; Bartter, Thaddeus; Dunn, Michael A.; Ruiz-Margain, Astrid; Kim, W. Ray; Duarte-Rojo, Andres
- Issue Date
- Nov-2020
- Publisher
- SPRINGER
- Keywords
- Frailty; Sarcopenia; Prehabilitation; Exercise
- Citation
- DIGESTIVE DISEASES AND SCIENCES, v.65, no.11, pp.3350 - 3359
- Journal Title
- DIGESTIVE DISEASES AND SCIENCES
- Volume
- 65
- Number
- 11
- Start Page
- 3350
- End Page
- 3359
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87481
- DOI
- 10.1007/s10620-019-06034-2
- ISSN
- 0163-2116
- Abstract
- Introduction A decline in physical function is highly prevalent and a poor prognostic factor in cirrhosis. We assessed the benefits of a home-based physical activity program (HB-PAP) in patients with cirrhosis with a randomized pilot trial. Methods All participants received a personal activity tracker to monitor daily activities and were given 12 g/day of an essential amino acid supplement. The HB-PAP intervention consisted of biweekly counseling sessions to increase physical activity for 12 weeks. Six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) assessed changes in aerobic fitness. Different anthropometric measuring tools were used for skeletal muscle and adiposity assessment. Results Seventeen patients (60% male; 29% nonalcoholic steatohepatitis/cryptogenic, 29% hepatitis C, 24% alcohol, 18% other) were randomized, 9 to HB-PAP group. There were no significant differences in MELD-sodium between HB-PAP and controls at baseline or after the 12-week intervention. By the end of study, there was a significant between-group difference in daily step count favoring the active group (2627 [992-4262],p = 0.001), with less sedentary patients in the active group (33-17% vs. 25-43%,p = 0.003). The 6MWT improved in the HB-PAP group (423 +/- 26 m vs. 482 +/- 35 m), while the controls had a nonsignificant drop (418 +/- 26 m vs. 327 +/- 74 m) with a significant between-group difference. CPET did not change. Other than an improvement in psoas muscle index, there were no differences in anthropometry, or in quality of life. Conclusions HB-PAP maintained physical performance and improved aerobic fitness according to 6MWT but not CPET, supporting the use of personal activity trackers to monitor/guide home-based prehabilitation programs in cirrhosis.
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