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Modulation of melanin synthesis by amaranthus spp. L seed extract in melan-a cells
- Authors
- Seo, J.O.; Do, M.H.; Lee, J.H.; Lee, T.H.; Wahedi, H.M.; Park, Y.U.; Kim, S.Y.
- Issue Date
- Sep-2016
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Amaranth; Melan-a cells; Melanogenesis; Myo-inositol
- Citation
- Natural Product Sciences, v.22, no.3, pp.168 - 174
- Journal Title
- Natural Product Sciences
- Volume
- 22
- Number
- 3
- Start Page
- 168
- End Page
- 174
- ISSN
- 1226-3907
- Abstract
- Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food. © 2016, Korean Society of Pharmacognosy. All rights reserved.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)