Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sitesopen access
- Authors
- Song, Joseph W.; Ryu, Hanjun; Bai, Wubin; Xie, Zhaoqian; Vazquez-Guardado, Abraham; Nandoliya, Khizar; Avila, Raudel; Lee, Geumbee; Song, Zhen; Kim, Jihye; Lee, Min-Kyu; Liu, Yugang; Kim, Mirae; Wang, Huifeng; Wu, Yixin; Yoon, Hong-Joon; Kwak, Sung Soo; Shin, Jaeho; Kwon, Kyeongha; Lu, Wei; Chen, Xuexian; Huang, Yonggang; Ameer, Guillermo A.; Rogers, John A.
- Issue Date
- Feb-2023
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE ADVANCES, v.9, no.8
- Journal Title
- SCIENCE ADVANCES
- Volume
- 9
- Number
- 8
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87802
- DOI
- 10.1126/sciadv.ade4687
- ISSN
- 2375-2548
- Abstract
- Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.