Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairmentopen access
- Authors
- Chang, Ha Kyun; Park, Young Hoon; Choi, Jung-A; Kim, Jeong Won; Kim, Jisup; Kim, Hyo Sun; Lee, Hae Nam; Cho, Hanbyoul; Chung, Joon-Yong; Kim, Jae-Hoon
- Issue Date
- May-2023
- Publisher
- MDPI
- Keywords
- Nectin-4; endometrial cancer; MSH2; MSH6
- Citation
- CANCERS, v.15, no.10
- Journal Title
- CANCERS
- Volume
- 15
- Number
- 10
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88223
- DOI
- 10.3390/cancers15102865
- ISSN
- 2072-6694
- Abstract
- The adhesion molecule Nectin-4 is a new potential therapeutic target for different types of cancer; however, little is known about its diagnosis significance in endometrial cancer (EC). We found that Nectin-4 expression was significantly higher in EC tissues than in nonadjacent normal tissue. The area under the receiver operating characteristic curve value of 0.922 indicated good diagnostic accuracy for Nectin-4 expression in EC. Furthermore, Nectin-4 expression was associated with DNA mismatch repair (MMR) protein deficiency. Notably, the high Nectin-4 expression group of patients with MSH2/6-deficient EC had shorter progression-free survival than that of the low Nectin-4 expression group. The number of lymphovascular space invasion-positive patients in groups with MMR deficiency and high Nectin-4 expression was also increased compared with that in the low Nectin-4 expression group. Bioinformatics analysis revealed that alteration in Nectin-4 and MMR genes is associated with Nectin-4 expression in EC. To the best of our knowledge, this is the first study to show that Nectin-4 expression may be a potential biomarker for EC diagnosis and that high Nectin-4 expression in MMR-deficient patients with EC can predict short progression-free survival, thus providing clues to identify patients for adjuvant therapy.
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