Chronic exposure to dexamethasone may not affect sugammadex reversal of rocuronium-induced neuromuscular blockade: an in vivo study on ratsopen access
- Authors
- Park, Ha Yeon; Choi, Hey-Ran; Kim, Yong Beom; Oh, Seok Kyeong; Kim, Taehoon; Yang, Hong Seuk; In, Junyong
- Issue Date
- Jul-2023
- Publisher
- 대한마취통증의학회
- Keywords
- Dexamethasone; Neuromuscular blockade; Neuromuscular monitoring; Rats; Rocuronium; Sugammadex.
- Citation
- Anesthesia and Pain Medicine, v.18, no.3, pp.275 - 283
- Journal Title
- Anesthesia and Pain Medicine
- Volume
- 18
- Number
- 3
- Start Page
- 275
- End Page
- 283
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88672
- DOI
- 10.17085/apm.23021
- ISSN
- 1975-5171
- Abstract
- Background: Chronic glucocorticoid exposure is associated with resistance to nondepolarizing neuromuscular blocking agents. Therefore, we hypothesized that sugammadex-induced recovery would occur more rapidly in subjects exposed to chronic dexamethasone compared to those who were not exposed. This study evaluated the sugammadex-induced recovery profile after neuromuscular blockade (NMB) in rats exposed to chronic dexamethasone.Methods: Sprague–Dawley rats were allocated to three groups (dexamethasone, control, and pair-fed group) for the in vivo study. The mice received daily intraperitoneal dexamethasone injections (500 μg/kg) or 0.9% saline for 15 days. To achieve complete NMB, 3.5 mg/kg rocuronium was administered on the sixteenth day. The recovery time to a train-of-four ratio ≥ 0.9 was measured to evaluate the complete recovery following the sugammadex injection.Results: Among the groups, no significant differences were observed in the recovery time to a train-of-four ratio ≥ 0.9 following sugammadex administration (P = 0.531). The time to the second twitch of the train-of-four recovery following rocuronium administration indicated that the duration of NMB was significantly shorter in Group D than that in Groups C and P (P = 0.001).Conclusions: Chronic exposure to dexamethasone did not shorten the recovery time of sugammadex-induced NMB reversal. However, the findings of this study indicated that no adjustments to sugammadex dosage or route of administration is required, even in patients undergoing long-term steroid treatment.
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