6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Modelopen access
- Authors
- Huh, Eugene; Choi, Jin Gyu; Choi, Yujin; Ju, In Gyoung; Noh, Dongjin; Shin, Dong-yun; Kim, Dong Hyun; Park, Hi-Joon; Oh, Myung Sook
- Issue Date
- Jul-2023
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Parkinson's disease; Microbiota-Gut-Brain axis; 6-shogaol; ginger; Proteus mirabilis
- Citation
- BIOMOLECULES & THERAPEUTICS, v.31, no.4, pp 417 - 424
- Pages
- 8
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 31
- Number
- 4
- Start Page
- 417
- End Page
- 424
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88745
- DOI
- 10.4062/biomolther.2023.098
- ISSN
- 1976-9148
2005-4483
- Abstract
- Parkinson's disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In the present study, we investigated whether 6-shogaol and ginger attenuate degenera-tion induced by Proteus mirabilis (P. mirabilis) on the intestine and brain, simultaneously. C57BL/6J mice received P. mirabilis for 5 days. Ginger (300 mg/kg) and 6-shogaol (10 mg/kg) were treated by gavage feeding for 22 days including the period of P. mirabilis treatment. Results showed that 6-shogaol and ginger improved motor dysfunction and dopaminergic neuronal death induced by P. mirabilis treatment. In addition, they suppressed P. mirabilis-induced intestinal barrier disruption, pro-inflammatory signals such as toll-like receptor and TNF-& alpha;, and intestinal & alpha;-synuclein aggregation. Moreover, ginger and 6-shogaol significantly inhibited neu-roinflammation and & alpha;-synuclein in the brain. Taken together, 6-shogaol and ginger have the potential to ameliorate PD-like motor behavior and degeneration of dopaminergic neurons induced by P. mirabilis in mice. Here, these findings are meaningful in that they provide the first experimental evidence that 6-shogaol might attenuate PD via regulating gut-brain axis.
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