Comparable humoral and cellular immunity against Omicron variant BA.4/5 of once-boosted BA.1/2 convalescents and twice-boosted COVID-19-naïve individuals
- Authors
- Kang, Chang Kyung; Kim, Min-Gang; Park, Seong-wook; Kim, Yong-Woo; Lee, Chan Mi; Choe, Pyoeng Gyun; Park, Wan Beom; Kim, Nam Joong; Kim, Minji; Lee, Soojin; Kim, Ik Soo; Lee, Chang-Han; Shin, Hyun Mu; Kim, Hang-Rae; Oh, Myoung-don
- Issue Date
- Feb-2023
- Publisher
- WILEY
- Keywords
- COVID-19; hybrid immunity; Omicron variant; SARS-CoV-2; vaccination
- Citation
- Journal of Medical Virology, v.95, no.2
- Journal Title
- Journal of Medical Virology
- Volume
- 95
- Number
- 2
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88784
- DOI
- 10.1002/jmv.28558
- ISSN
- 0146-6615
1096-9071
- Abstract
- The fourth vaccination dose confers additional protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with no prior coronavirus disease-19 (COVID-19). However, its immunological benefit against currently circulating BA.4/5 is unclear in individuals who have received a booster shot and been infected with Omicron variant BA.1/2. We analyzed immune responses in whom had been boosted once and did not have COVID-19 (n = 16), boosted once and had COVID-19 when BA.1/2 was dominant in Korea (Hybrid-6M group, n = 27), and boosted twice and did not have COVID-19 (Vx4 group, n = 15). Antibody binding activities against RBDo BA.1 and RBDo BA.4/5, antigen-specific memory CD4+ and CD8+ T-cell responses against BA.4/5, and B-cell responses against SARS-CoV-2 wild-type did not differ statistically between the Hybrid-6M and Vx4 groups. The humoral and cellular immune responses of the Hybrid-6M group against BA.4/5 were comparable to those of the Vx4 group. Individuals who had been boosted and had an Omicron infection in early 2022 may not have high priority for an additional vaccination. © 2023 Wiley Periodicals LLC.
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