Xinghamide A, a New Cyclic Nonapeptide Found in Streptomyces xinghaiensisopen access
- Authors
- Um, Soohyun; Lee, Jaeyoun; Kim, Sung Jin; Cho, Kyung A.; Kang, Ki Sung; Kim, Seung Hyun
- Issue Date
- Oct-2023
- Publisher
- MDPI
- Keywords
- nonapeptide; halophile; Streptomyces xinghaiensis; anti-inflammation
- Citation
- MARINE DRUGS, v.21, no.10
- Journal Title
- MARINE DRUGS
- Volume
- 21
- Number
- 10
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89620
- DOI
- 10.3390/md21100509
- ISSN
- 1660-3397
1660-3397
- Abstract
- Xinghamide A (1), a new nonapeptide, was discovered in Streptomyces xinghaiensis isolated from a halophyte, Suaeda maritima (L.) Dumort. Based on high-resolution mass and NMR spectroscopic data, the planar structure of 1 was established, and, in particular, the sequence of nine amino acids was determined with ROESY and HMBC NMR spectra. The absolute configurations of the alpha-carbon of each amino acid residue were determined with 1-fluoro-2,4-dinitrophenyl-l-and -d-leucine amide (Marfey's reagents) and 2,3,4,6-tetra-O-acetyl-beta-d-glucopyranosyl isothiocyanate, followed by LC-MS analysis. The anti-inflammatory activity of xinghamide A (1) was evaluated by inhibitory abilities against the nitric oxide (NO) secretion and cyclooxygenase-2 (COX-2) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
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