Factors for achieving target serum uric acid levels after initiating urate-lowering therapy in patients with gout: results from the ULTRA registryopen access
- Authors
- Do, Hyunsue; Choi, Hyo Jin; Choi, Byoongyong; Son, Chang-Nam; Kim, Sang-Hyon; Choi, Se Rim; Kim, Ji Hyoun; Kim, Min Jung; Shin, Kichul; Kim, Hyun-Ok; Song, Ran; Lee, Sung Won; Ahn, Joong Kyong; Lee, Seung-Geun; Lee, Chang Hoon; Son, Kyeong Min; Moon, Ki Won
- Issue Date
- Nov-2023
- Publisher
- NATURE PORTFOLIO
- Citation
- SCIENTIFIC REPORTS, v.13, no.1
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 13
- Number
- 1
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90144
- DOI
- 10.1038/s41598-023-47790-6
- ISSN
- 2045-2322
- Abstract
- Achieving target serum uric acid (SUA) levels is important in gout management. Guidelines recommend lowering SUA levels to < 6 mg/dL; however, many patients fail to reach this target, even with uric acid-lowering therapy (ULT). This study investigated clinical characteristics of target SUA achievers among Korean patients with gout. This study used data from the ULTRA registry, a nationwide inception cohort established in September 2021 that enrolls patients with gout who initiate ULT. Demographic, clinical, and laboratory data were collected at baseline; the 6-month follow-up. Patients were divided into two groups: target achievers (SUA level < 6 mg/dL at 6 months) and non-achievers. The mean participant (N = 117) age was 56.1 years, and 88.0% were male. At 6 months, 83 patients (70.9%) reached target SUA levels. Target achievers had better drug adherence (>= 80%) to ULT (97.6% vs. 76.5%; p < 0.01) than non-achievers. Target non-achievers had a higher percentage of a family history of gout (32.4% vs. 10.8%; p < 0.01) and less antihypertensive agent use (38.2% vs. 59.0%; p = 0.03) than target achievers. Multivariate regression analysis revealed that good adherence to ULT, the absence of a family history of gout, and antihypertensive agent use were key factors associated with achieving target SUA levels at 6 months.
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