The Usefulness of 18F-FDG PET to Differentiate Subtypes of Dementia: The Systematic Review and Meta-Analysis
- Authors
- Na, Seunghee; Kang, Dong Woo; Kim, Geon Ha; Kim, Ko Woon; Kim, Yeshin; Kim, Hee-Jin; Park, Kee Hyung; Park, Young Ho; Byeon, Gihwan; Suh, Jeewon; Shin, Joon Hyun; Shim, YongSoo; Yang, YoungSoon; Um, Yoo Hyun; Oh, Seong-il; Wang, Sheng-Min; Yoon, Bora; Yoon, Hai-Jeon; Lee, Sun Min; Lee, Juyoun; Lee, Jin San; Rhee, Hak Young; Lim, Jae-Sung; Jung, Young Hee; Chin, Juhee; Hong, Yun Jeong; Jang, Hyemin; Choi, Hongyoon; Choi, Miyoung; Jang, Jae-Won
- Issue Date
- Jan-2024
- Publisher
- 대한치매학회
- Keywords
- Fluorodeoxyglucose F18; Positron Emission Tomography Computed Tomography; Dementia; Meta-Analysis; Alzheimer’s Disease; Frontotemporal Dementia; Lewy Body Disease
- Citation
- Dementia and Neurocognitive Disorders(대한치매학회지), v.23, no.1, pp 54 - 66
- Pages
- 13
- Journal Title
- Dementia and Neurocognitive Disorders(대한치매학회지)
- Volume
- 23
- Number
- 1
- Start Page
- 54
- End Page
- 66
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90346
- DOI
- 10.12779/dnd.2024.23.1.54
- ISSN
- 1738-1495
2384-0757
- Abstract
- Background and Purpose: Dementia subtypes, including Alzheimer’s dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) in differentiating these subtypes for precise treatment and management.
Methods: A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of 18F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the gold-standard clinical diagnosis for dementia subtypes.
Results: From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88–0.98) and specificity was 0.84 (95% CI, 0.70–0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70–0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80–0.91) and the specificity was 0.88 (95% CI, 0.80–0.91). The studies mostly used case-control designs with visual and quantitative assessments.
Conclusions: 18F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.
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