Predictive performance of the new race-free Chronic Kidney Disease Epidemiology Collaboration equations for kidney outcome in Korean patients with chronic kidney diseaseopen access
- Authors
- Kim, Hyoungnae; Hyun, Young Youl; Yun, Hae-Ryong; Joo, Young Su; Kim, Yaeni; Jung, Ji Yong; Jeong, Jong Cheol; Kim, Jayoun; Park, Jung Tak; Yoo, Tae-Hyun; Kang, Shin-Wook; Oh, Kook-Hwan; Han, Seung Hyeok
- Issue Date
- Jul-2023
- Publisher
- KOREAN SOC NEPHROLOGY
- Keywords
- Chronic Kidney Disease Epidemiology Collaboration; Creatinine; Cystatin C; Kidney failure with renal replacement therapy
- Citation
- KIDNEY RESEARCH AND CLINICAL PRACTICE, v.42, no.4, pp 501 - 511
- Pages
- 11
- Journal Title
- KIDNEY RESEARCH AND CLINICAL PRACTICE
- Volume
- 42
- Number
- 4
- Start Page
- 501
- End Page
- 511
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/90751
- DOI
- 10.23876/j.krcp.22.158
- ISSN
- 2211-9132
2211-9140
- Abstract
- Background: The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations without a race coefficient have gained recognition across the United States. We aimed to test whether these new equations performed well in Korean patients with chronic kidney disease (CKD). Methods: This study included 2,149 patients with CKD G1-G5 without kidney replacement therapy from the Korean Cohort Study for Outcome in Patients with CKD (KNOW-CKD). The estimated glomerular filtration rate (eGFR) was calculated using the new CKD-EPI equations with serum creatinine and cystatin C. The primary outcome was 5-year risk of kidney failure with replacement therapy (KFRT). Results: When we adopted the new creatinine equation [eGFRcr (NEW)], 81 patients (23.1%) with CKD G3a based on the current cre-atinine equation (eGFRcr) were reclassified as CKD G2. Accordingly, the number of patients with eGFR of <60 mL/min/1.73 m2 de-creased from 1,393 (64.8%) to 1,312 (61.1%). The time-dependent area under the receiver operating characteristic curve for 5-year KFRT risk was comparable between the eGFRcr (NEW) (0.941; 95% confidence interval [CI], 0.922-0.960) and eGFRcr (0.941; 95% CI, 0.922-0.961). The eGFRcr (NEW) showed slightly better discrimination and reclassification than the eGFRcr. However, the new cre-atinine and cystatin C equation [eGFRcr-cys (NEW)] performed similarly to the current creatinine and cystatin C equation. Furthermore, eGFRcr-cys (NEW) did not show better performance for KFRT risk than eGFRcr (NEW). Conclusion: Both the current and the new CKD-EPI equations showed excellent predictive performance for 5-year KFRT risk in Kore-an patients with CKD. These new equations need to be further tested for other clinical outcomes in Koreans.
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