A Two-Year Observational Study to Evaluate Conversion Rates from High- and Low-Risk Patients with Amnestic Mild Cognitive Impairment to Probable Alzheimer's Disease in a Real-World Settingopen access
- Authors
- Jang, H.; Na, D.L.; Kwon, J.C.; Jung, N.-Y.; Moon, Y.; Lee, J.S.; Park, K.-W.; Lee, A.Y.; Cho, H.; Lee, J.-H.; Kim, B.C.; Park, K.H.; Lee, B.-C.; Choi, H.; Kim, J.; Park, M.Y.
- Issue Date
- May-2024
- Publisher
- IOS Press BV
- Keywords
- Alzheimer's disease; amnestic mild cognitive impairment; conversion rate; neurodegeneration; neuropsychometry; nomogram
- Citation
- Journal of Alzheimer's Disease Reports, v.8, no.1, pp 851 - 862
- Pages
- 12
- Journal Title
- Journal of Alzheimer's Disease Reports
- Volume
- 8
- Number
- 1
- Start Page
- 851
- End Page
- 862
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91370
- DOI
- 10.3233/ADR-230189
- ISSN
- 2542-4823
2542-4823
- Abstract
- Background: Predicting conversion to probable Alzheimers disease (AD) from amnestic mild cognitive impairment (aMCI) is difficult but important. A nomogram was developed previously for determining the risk of 3-year probable AD conversion in aMCI. Objective: To compare the probable AD conversion rates with cognitive and neurodegenerative changes for 2 years from high- and low risk aMCI groups classified using the nomogram. Methods: This prospective, multicenter, observational study was conducted in Korea. A total of patients were classified as high- or low-risk aMCI according to the nomogram and followed-up for 2 years to compare the annual conversion rate to probable AD and brain structure changes between the two groups. Results: In total, 176 (high-risk, 85; low-risk, 91) and 160 (high-risk, 77; low-risk, 83) patients completed the 1-year and 2-year follow-up, respectively. The probable AD conversion rate was significantly higher in the high-risk (Year 1, 28.9%; Year 2, 46.1%) versus low-risk group (Year 1, 0.0%; Year 2, 4.9%, both p < 0.0001). Mean changes from baseline in Seoul Neuropsychological Screening Battery-Dementia Version, Clinical Dementia Rating-Sum of Box, and Korean version of the Instrumental Activities of Daily Living scores and cortical atrophy index at Years 1 and 2 were significantly greater in the high-risk group (p < 0.0001). Conclusions: The high-risk aMCI group, as determined by the nomogram, had a higher conversion rate to probable AD and faster cognitive decline and neurodegeneration change than the low-risk group. These real-world results have clinical implications that help clinicians in accurately predicting patient outcomes and facilitating early decision-making. Trial Registration: ClinicalTrials.gov (NCT03448445) © 2024 - The authors. Published by IOS Press.
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