Rosarugosides A and D from Rosa rugosa Flower Buds: Their Potential Anti-Skin-Aging Effects in TNF-α-Induced Human Dermal Fibroblastsopen access
- Authors
- Kim, Kang Sub; Son, So-Ri; Choi, Yea Jung; Kim, Yejin; Ahn, Si-Young; Jang, Dae Sik; Lee, Sullim
- Issue Date
- May-2024
- Publisher
- MDPI
- Keywords
- Rosa rugosa; depsides; TNF-alpha; ROS; MMP-1; procollagen type Iota alpha 1
- Citation
- PLANTS-BASEL, v.13, no.9
- Journal Title
- PLANTS-BASEL
- Volume
- 13
- Number
- 9
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/91528
- DOI
- 10.3390/plants13091266
- ISSN
- 2223-7747
- Abstract
- This present study investigated the anti-skin-aging properties of Rosa rugosa. Initially, phenolic compounds were isolated from a hot water extract of Rosa rugosa's flower buds. Through repeated chromatography (column chromatography, MPLC, and prep HPLC), we identified nine phenolic compounds (1-9), including a previously undescribed depside, rosarugoside D (1). The chemical structure of 1 was elucidated via NMR, HR-MS, UV, and hydrolysis. Next, in order to identify bioactive compounds that are effective against TNF-alpha-induced NHDF cells, we measured intracellular ROS production in samples treated with each of the isolated compounds (1-9). All isolates reduced the level of ROS at a concentration of 10 mu M. Particularly, two depsides-rosarugosides A and D (2 and 1)-significantly inhibited ROS expression in TNF-alpha-induced NHDFs compared to the other phenolic compounds. Subsequently, the production of MMP-1 and procollagen type Iota alpha 1 by these two depsides was examined. Remarkably, rosarugoside A (2) significantly decreased MMP-1 secretion at all concentrations. In contrast, rosarugoside D (1) regulated the expression of procollagen type Iota alpha 1. These findings collectively suggest that Rosa rugosa extracts and their isolated compounds, rosarugosides A (2) and D (1), hold significant potential for protecting against aging and skin damage. Overall, these findings suggest that Rosa rugosa extracts and their isolated compounds, rosarugosides A (2) and D (1), have the potential to prevent and protect against aging and skin damage, although more specific quantitative analysis is needed.
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