Oxidative stress-mediated deleterious effects of hypoxia in the brackish water flea Diaphanosoma celebensis
- Authors
- Lee, Yoseop; Kim, Duck-Hyun; Lee, Jin-Sol; Lee, Min-Chul; Kim, Hyung Sik; Maszczyk, Piotr; Sakakura, Yoshitaka; Yang, Zhou; Hagiwara, Atsushi; Park, Heum Gi; Lee, Jae-Seong
- Issue Date
- Aug-2024
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Hypoxia; Oxidative stress; Antioxidant system; HIF-1 alpha pathway; Diaphanosoma celebensis
- Citation
- MARINE POLLUTION BULLETIN, v.205
- Journal Title
- MARINE POLLUTION BULLETIN
- Volume
- 205
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/92093
- DOI
- 10.1016/j.marpolbul.2024.116633
- ISSN
- 0025-326X
1879-3363
- Abstract
- In this study, we investigated the acute toxicity, in vivo effects, oxidative stress, and gene expression changes caused by hypoxia on the brackish water flea Diaphanosoma celebensis. The no-observed-effect concentration (NOEC) of 48 h of hypoxia exposure was found to be 2 mg/L O2. Chronic exposure to NOEC caused a significant decline in lifespan but had no effect on total fecundity. The induction of reactive oxygen species increased in a time-dependent manner over 48 h, whereas the content of antioxidant enzymes (superoxide dismutase and catalase) decreased. The transcription and translation levels were modulated by hypoxia exposure. In particular, a significant increase in hemoglobin level was followed by up-regulation of hypoxia-inducible factor 1 alpha gene expression and activation of the mitogen-activated protein kinase pathway. In conclusion, our findings provide a better understanding of the molecular mechanism of the adverse effects of hypoxia in brackish water zooplankton.
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