Regulation of IL-24 in human oral keratinocytes stimulated with Tannerella forsythia
- Authors
- Ko, Yeon-Kyeong; An, Sun-Jin; Han, Na-Young; Lee, Hookeun; Choi, Bong-Kyu
- Issue Date
- Oct-2019
- Publisher
- WILEY
- Keywords
- IL-24; oral keratinocytes; periodontal pathogen; reactive oxygen species
- Citation
- MOLECULAR ORAL MICROBIOLOGY, v.34, no.5, pp.209 - 218
- Journal Title
- MOLECULAR ORAL MICROBIOLOGY
- Volume
- 34
- Number
- 5
- Start Page
- 209
- End Page
- 218
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/924
- DOI
- 10.1111/omi.12265
- ISSN
- 2041-1006
- Abstract
- Interleukin-24 is a pleiotropic immunoregulatory cytokine and a member of the IL-20R subfamily of the IL-10 family. The aim of this study was to investigate the regulation of IL-24 in the human oral keratinocyte cell line HOK-16B following infection with Tannerella forsythia, a major periodontal pathogen. T. forsythia induced the expression of IL-24 mRNA and the secretion of glycosylated IL-24 in HOK-16B cells. Glycosylation of IL-24 is linked to its solubility and bioavailability. T. forsythia-stimulated reactive oxygen species (ROS) induced the expression of IL-24, which was regulated by IL-6. The ROS inhibitor N-acetylcysteine and MAPK inhibitors significantly reduced the expression of IL-6 and IL-24 induced by T. forsythia. Recombinant human IL-24 significantly enhanced the expression of IL-1 alpha, IL-8, CXCL10, and MCP-1 in HOK-16B cells. Together, these results indicate that ROS, MAPKs, and IL-6 comprise the axis of IL-24 expression in HOK-16B cells stimulated with T. forsythia. Thus, IL-24 may be involved in inflammation in oral keratinocytes.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/924)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.