Association between tumor necrosis factor-alpha (TNF-alpha) polymorphism (-308, G/A) and acute rejection of solid organ allograft: a meta-analysis
- Authors
- Park, Sang-Kyu; Kim, Su-Kang; Kang, Sang-Wook; Kim, Bo-Kyun; Chung, Joo-Ho; Park, Min-Su
- Issue Date
- 2016
- Publisher
- E-CENTURY PUBLISHING CORP
- Keywords
- Tumor necrosis factor-alpha; polymorphism; acute rejection; meta-analysis
- Citation
- INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, v.9, no.9, pp.17060 - 17068
- Journal Title
- INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
- Volume
- 9
- Number
- 9
- Start Page
- 17060
- End Page
- 17068
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9763
- ISSN
- 1940-5901
- Abstract
- The association between gene polymorphisms of tumor necrosis factor-alpha (TNF-alpha) and risk of acute rejection (AR) of solid organ allograft was investigated in many published studies; however, the currently available results are inconclusive. Therefore, we performed a meta-analysis to provide a precise evidence for an association between the TNF-alpha polymorphism and risk of AR. A comprehensive electronic search of PUBMED, EMBASE, scholar of google, and Korean databases was performed until June 1, 2015. Meta-analysis was performed using the comprehensive meta-analysis software (Corporation, NJ, USA). The pooled p value, OR and 95% CI were used to measure the strength of the association with TNF-alpha. Forty five eligible studies were included in this meta-analysis. Our study revealed that combined genotype (A/A genotype + A/G genotype) was contributed to susceptibility of AR in solid organ recipients (OR = 1.424, 95% CI = 1.118-1.813, P = 0.004). Moreover, the Egger's test showed quantitative evidence for absence of publication bias (P = 0.149). This meta-analysis indicated the TNF-a polymorphism (-308, G/A) might be genetic risk factors for acute rejection. However, more studies with larger sample size were needed to provide more precise evidence.
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