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Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
- Authors
- Park, Cheon-Soo; Ahn, Yongchel; Lee, Dahae; Moon, Sung Won; Kim, Ki Hyun; Yamabe, Noriko; Hwang, Gwi Seo; Jang, Hyuk Jai; Lee, Heesu; Kang, Ki Sung; Lee, Jae Wook
- Issue Date
- 15-Dec-2015
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Chalcone; Anticancer; HepG2; Apoptosis
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.24, pp.5705 - 5707
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 25
- Number
- 24
- Start Page
- 5705
- End Page
- 5707
- ISSN
- 0960-894X
- Abstract
- Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway. (C) 2015 Elsevier Ltd. All rights reserved.
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Related Researcher
- Kang, Ki Sung
- College of Korean Medicine (Premedical course of Oriental Medicine)