In-vitro cytotoxicity assessment of carbon-nanodot-conjugated Fe-aminoclay (CD-FeAC) and its bio-imaging applications
- Authors
- Kang, Kyoung Suk; Lee, Hyun Uk; Kim, Moon Il; Park, So Young; Chang, Sung-Jin; Park, Ji-Ho; Huh, Yun Suk; Lee, Jouhahn; Yang, Mino; Lee, Young-Chul; Park, Hyun Gyu
- Issue Date
- 26-Nov-2015
- Publisher
- BMC
- Keywords
- In-vitro cytotoxicity; Fe-aminoclay (FeAC); Carbon nanodots (CD); Cytotoxicity; Conjugation; Bio-imaging
- Citation
- JOURNAL OF NANOBIOTECHNOLOGY, v.13
- Journal Title
- JOURNAL OF NANOBIOTECHNOLOGY
- Volume
- 13
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9920
- DOI
- 10.1186/s12951-015-0151-z
- ISSN
- 1477-3155
- Abstract
- We have investigated the cytotoxic assay of Fe-aminoclay (FeAC) nanoparticles (NPs) and simultaneous imaging in HeLa cells by photoluminescent carbon nanodots (CD) conjugation. Non-cytotoxic, photostable, and CD NPs are conjugated with cationic FeAC NPs where CD NPs play a role in bio-imaging and FeAC NPs act as a substrate for CD conjugation and help to uptake of NPs into cancer cells due to positively charged surface of FeAC NPs in physiological media. As increase of CD-FeAC NPs loading in HeLa cell in vitro, it showed slight cytotoxicity at 1000 mu g/mL but no cytotoxicity for normal cells up to concentration of 1000 mu g/mL confirmed by two 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red (NR) assays, with further observations by 4', 6-diamidino-2-phenylindole (DAPI) stained confocal microscopy images, possessing that CD-FeAC NPs can be used as potential drug delivery platforms in cancer cells with simultaneous imaging.
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