A new naphthalene glycoside from Chimaphila umbellata inhibits the RANKL-stimulated osteoclast differentiation
- Authors
- Shin, Byong-kyu; Kim, Jinhee; Kang, Ki Sung; Piao, Hui-Shan; Park, Jeong Hill; Hwang, Gwi Seo
- Issue Date
- Nov-2015
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Chimaphila umbellata; 2,7-Dimethyl-1,4-dihydroxynaphthalene-1-O-beta-D-glucopyranoside; Osteoclast; Receptor activator of nuclear factor-kappa B ligand; Tartrate-resistant acid phosphatase
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.38, no.11, pp.2059 - 2065
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 38
- Number
- 11
- Start Page
- 2059
- End Page
- 2065
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/9973
- DOI
- 10.1007/s12272-015-0598-3
- ISSN
- 0253-6269
- Abstract
- A new naphthalene glycoside was isolated from the leaves and stems of Chimaphila umbellata Barton. Its chemical structure was elucidated to be 2,7-dimethyl-1,4-dihydroxynaphthalene-1-O-beta-d-glucopyranoside (DMDHNG), based on spectroscopic evidence. DMDHNG significantly inhibited the receptor activator of nuclear factor-kappa B ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity and the formation of multinucleated osteoclasts in a dose-dependent manner. In addition, the new glycoside inhibited the RANKL-induced mRNA expression of osteoclast-associated genes that encode TRAP, cathepsin K, and another transcription factor-nuclear factor of activated T-cells c1. We believe that the inhibitory effects of DMDHNG on the osteoclast differentiation may be exploited for a therapeutic benefit.
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