Ratio of triglyceride to high-density lipoprotein cholesterol and risk of major cardiovascular events in kidney transplant recipientsopen access
- Authors
- Kim, Ji Eun; Yu, Mi-Yeon; Kim, Yong Chul; Min, Sang-il; Ha, Jongwon; Lee, Jung Pyo; Kim, Dong Ki; Oh, Kook-Hwan; Joo, Kwon-Wook; Ahn, Curie; Kim, Yon Su; Lee, Hajeong
- Issue Date
- Dec-2019
- Publisher
- SPRINGER
- Keywords
- Cholesterol; Cardiovascular; TG; HDL-C; Statins; Kidney transplantation
- Citation
- CLINICAL AND EXPERIMENTAL NEPHROLOGY, v.23, no.12, pp 1407 - 1417
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND EXPERIMENTAL NEPHROLOGY
- Volume
- 23
- Number
- 12
- Start Page
- 1407
- End Page
- 1417
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/11601
- DOI
- 10.1007/s10157-019-01776-9
- ISSN
- 1342-1751
1437-7799
- Abstract
- Background
Dyslipidemia is common in kidney transplant (KT) recipients. We analyzed the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) in KT recipients to identify risk factors for major cardiovascular events (MACE).
Methods
We retrospectively included KT recipients with a lipid profile performed 1 year after transplantation. We classified patients according to the TG/HDL-C divided into quintiles. Subsequently, we analyzed the association between TG/HDL-C and MACE, defined as heart failure, coronary artery disease, and cerebrovascular disease confirmed by imaging studies.
Results
A total of 1301 KT recipients were enrolled. The median follow-up duration was 7.4 years (interquartile range 4.4–11.1 years). During the follow-up period, 80 (6.2%) patients developed MACE, which included 38 of unstable anginas, 9 of MIs, 19 of heart failures, 18 of cerebral infarcts, and 4 of cerebral hemorrhages. The fourth and fifth quintiles of TG/HDL-C showed a significantly increased risk of MACE [fourth quintile: adjusted hazard ratio (aHR), 3.38; 95% confidence interval (CI) 1.44–7.95; p = 0.005, fifth quintile: aHR, 2.67; 95% CI 1.13–6.30; p = 0.02]) compared to the second quintile of TG/HDL-C. This association is particularly evident in subgroups of non-DM, HTN, no history of CVD, and statin users.
Conclusions
Higher TG/HDL-C levels may be associated with MACE risk in KT recipients.
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