Effect of Muscle Cell Preservation on Viability and Differentiation of Hamstring Tendon Graft In Vitroopen access
- Authors
- Lee, Jin Kyu; Jo, Sungsin; Lee, Young Lim; Weon, Subin; Song, Jun-Seob; Sung, Il-Hoon; Kim, Tae-Hwan
- Issue Date
- Apr-2021
- Publisher
- MDPI
- Keywords
- anterior cruciate ligament reconstruction; tendon-derived cells; muscle-derived cells; multiple differentiation
- Citation
- CELLS, v.10, no.4, pp.1 - 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLS
- Volume
- 10
- Number
- 4
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1266
- DOI
- 10.3390/cells10040740
- ISSN
- 2073-4409
- Abstract
- Muscle tissue is often removed during hamstring tendon graft preparation for anterior cruciate ligament (ACL) reconstruction. The purpose of the study was to test whether preservation of muscle remnants on a tendon graft is beneficial to the graft healing process following ACL reconstruction. Co-culturing of tendon-derived cells (TDCs) and muscle-derived cells (MDCs) was performed at various ratios, and their potential for cell viability and multilineage differentiation was compared to a single TDC cell group. Ligamentous and chondrogenic differentiation was most enhanced when a small population of MDCs was co-cultured with TDCs (6:2 co-culture group). Cell viability and osteogenic differentiation were proportionally enhanced with increasing MDC population size. MDCs co-cultured with TDCs possess both the ability to enhance cell viability and differentiate into other cell lineages.
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Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
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