Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbiditiesopen access
- Authors
- Choi, Hayoung; Yang, Bumhee; Kim, Yun Jin; Sin, Sooim; Jo, Yong Suk; Kim, Youlim; Park, Hye Yun; Ra, Seung Won; Oh, Yeon-Mok; Chung, Sung Jun; Yeo, Yoomi; Park, Dong Won; Park, Tai Sun; Moon, Ji-Yong; Kim, Sang-Heon; Kim, Tae-Hyung; Yoon, Ho Joo; Sohn, Jang Won; Lee, Hyun
- Issue Date
- Mar-2021
- Publisher
- NATURE RESEARCH
- Citation
- SCIENTIFIC REPORTS, v.11, no.1, pp.1 - 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 11
- Number
- 1
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/1319
- DOI
- 10.1038/s41598-021-86407-8
- ISSN
- 2045-2322
- Abstract
- There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than in those without bronchiectasis. Using 2005-2015 data from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause mortality in the bronchiectasis cohort relative to the matched cohort. The effect of comorbidities over the study period on the relative mortality was also assessed. All-cause mortality was significantly higher in the bronchiectasis cohort than in the matched cohort (2505/100,000 vs 2142/100,000 person-years, respectively; P<0.001). Mortality risk was 1.15-fold greater in the bronchiectasis cohort than in the matched cohort (95% confidence interval [CI] 1.09-1.22); mortality was greatest among elderly patients (HR=1.17, 95% CI 1.10-1.25) and men (HR=1.19, 95% CI 1.10-1.29). Comorbidities over the study period significantly increased the risk of death in the bronchiectasis cohort relative to the matched cohort: asthma (adjusted HR=1.20, 95% CI 1.11-1.30), chronic obstructive pulmonary disease (adjusted HR=1.24, 95% CI 1.15-1.34), pneumonia (adjusted HR=1.50, 95% CI 1.39-1.63), lung cancer (adjusted HR=1.85, 95% CI 1.61-2.12), and cardiovascular disease (adjusted HR=1.34, 95% CI 1.23-1.45). In contrast, there were no significant differences in the risk of death in patients without bronchiectasis-related comorbidities and the matched cohort, except in the case of non-tuberculous mycobacterial infection. In conclusion, all-cause mortality was higher in patients with bronchiectasis cohort than those without bronchiectasis, especially in elderly patients and men. Comorbidities over the study period played a major role in increasing mortality in patients with bronchiectasis relative to those without bronchiectasis.
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