Nonsteroidal Anti-inflammatory Drugs-sparing Effect of Symptomatic Slow-acting Drugs for Osteoarthritis in Knee Osteoarthritis Patientsopen access
- Authors
- Cho, Soo-Kyung; Kim, Hyoungyoung; Park, Ha-Rim; Choi, Wooseok; Choi, Seongmi; Jung, Sun-Young; Jang, Eun Jin; Sung, Yoon-Kyoung
- Issue Date
- Jul-2019
- Publisher
- 대한류마티스학회
- Keywords
- Osteoarthritis; Symptomatic slow-acting drugs for osteoarthritis; Nonsteroidal anti-inflammatory drugs
- Citation
- 대한류마티스학회지, v.26, no.3, pp.179 - 185
- Indexed
- SCOPUS
KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 26
- Number
- 3
- Start Page
- 179
- End Page
- 185
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/13370
- DOI
- 10.4078/jrd.2019.26.3.179
- ISSN
- 2093-940X
- Abstract
- Objective. To evaluate the nonsteroidal anti-inflammatory drugs (NSAID)-sparing effect of symptomatic slow-acting drugs for osteoarthritis (SYSADOA) in knee osteoarthritis (OA) patients. Methods. A retrospective study was conducted on a cohort of knee OA patients who visited a single academic referral hospital from 2013 to 2014. Among all patients, NSAID users in their first visit were extracted and divided into SYSADOA users and SYSADOA non-users. All patients were observed from their first visit with knee OA to their last visit, NSAID discontinuation, or the date of data collection, July 2017 (mean observational periods: 369.1 days). To evaluate the NSAID-sparing effect of SYSADOA, Cox regression analysis was performed after adjusting for confounding factors. Results. Patients for this study (n=212) were divided into SYSADOA users (n=57) and SYSADOA non-users (n=155). The mean age (68.8 vs. 66.6 years old, p=0.31) and the number of comorbidities (p=0.73) were comparable between the two groups. The SYSADOA users showed higher Kellgren-Lawrence (KL) grade (66.7% of patients with more than KL grade 3) than SYSADOA non-users (42.6% of patients with more than KL grade 3) (p=0.02). In treatment, the frequency of intra-articular injection was higher in the SYSADOA user group than the SYSADOA non-user group (33.3% vs. 9.0%, p<0.01). In Cox regression analysis, SYSADOA use contributed to NSAID discontinuation in knee OA patients (hazard ratio 2.97, 95% confidential interval 1.42 similar to 6.22). Conclusion. This real-world analysis demonstrated that SYSADOA use combined with NSAIDs had a significant effect on NSAID discontinuation in patients with knee OA.
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