Effect of Metformin on Myocardial Injury Induced by Hepatic Ischemia-Reperfusion in Ratsopen access
- Authors
- An, Wen An; Kang, Ju-Seop
- Issue Date
- Apr-2022
- Publisher
- Frontiers Media S.A.
- Keywords
- hepatic injury; hepatic ischemia-reperfusion; metformin; myocardial injury; oxidative stress
- Citation
- Frontiers in Pharmacology, v.13, pp.1 - 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Frontiers in Pharmacology
- Volume
- 13
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138786
- DOI
- 10.3389/fphar.2022.822743
- ISSN
- 1663-9812
- Abstract
- Background: There is no effective medication for treatment or prevention of hepatic ischemia-reperfusion (HIR) injury caused by liver transplantation and hepatectomy. This study aimed to investigate the therapeutic effects of metformin on HIR injury and related myocardial injury in rats. Methods: Wistar male rats were randomly divided into four groups: sham group, ischemia-reperfusion group, and IR group treated with metformin 150 mg/kg and 100 mg/kg. Wistar male rats were administered metformin 150 mg/kg, 100 mg/kg or saline 30 min pre-operative and underwent 15 min ischemia and 6 h reperfusion (n = 4). Results: Metformin significantly alleviates the injury caused by HIR. Administration of metformin resulted in a significant reduction in the serum levels of alanine transaminase and aspartate transaminase and the activity of malondialdehyde, creatine kinase-MB, and lactate dehydrogenase but maintained high catalase and superoxide dismutase activity. Metformin significantly inhibited the IR-induced elevation of tumor necrosis factor-α in liver and heart tissue. Conclusion: Metformin can alleviate hepatic and myocardial injury induced by IR by inhibiting oxidative stress.
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