Chronic Obstructive Pulmonary Disease is Associated with a More Symptomatic Burden and Severe Presentation of COVID-19: A Korean National COVID-19 Cohort Studyopen access
- Authors
- Kim, Youlim; Lee, Hyun; Lee, Sun-Kyung; Yang, Bumhee; Choi, Hayoung; Park, Dong Won; Park, Tai Sun; Moon, Ji Yong; Kim, Tae Hyung; Sohn, Jang Won; Yoon, Ho Joo; Kim, Sang Heon
- Issue Date
- Mar-2022
- Publisher
- TOHOKU UNIV MEDICAL PRESS
- Keywords
- COPD; COVID-19 infection; disease severity; mortality; symptom burden
- Citation
- TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, v.256, no.3, pp.209 - 214
- Indexed
- SCIE
SCOPUS
- Journal Title
- TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- Volume
- 256
- Number
- 3
- Start Page
- 209
- End Page
- 214
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139287
- DOI
- 10.1620/tjem.256.209
- ISSN
- 0040-8727
- Abstract
- Insufficient data are available on comprehensive evaluation of demographics, symptoms or signs, laboratory findings, and disease course in patients with coronavirus disease 2019 (COVID-19) and chronic obstructive pulmonary disease (COPD). We aimed to evaluate whether COPD patients are more prone to severe COVID-19 compared with those without COPD. We also investigate the clinical characteristics and disease course of COVID-19 in patients with COPD versus those without COPD. Patients were selected from a Korean nationwide cohort of 5,628 patients with confirmed COVID-19 and who had completed treatment or quarantine by April 30, 2020; 3,673 patients aged 40 years or older were included in this study. COPD was diagnosed using patient reports of physician-diagnosed COPD. During the study period, all patients with COVID-19 in Korea were hospitalized following the national health policy. Of the study participants, 38 (1.0%) had COPD. Regarding initial symptoms, COPD patients with COVID-19 showed greater sputum production (50.0% vs. 29.8%, p < 0.01) and dyspnea (36.8% vs. 14.9%, p < 0.01) than those without COPD. In addition, patients with COPD were more likely to receive oxygen therapy or non-invasive ventilation (29.0% vs. 13.7%, p = 0.01) and had a higher mortality (21.1% vs. 6.4%, p < 0.01) than those without COPD. After adjusting for age, sex, body mass index, and comorbidities, COPD patients showed increased risk of severe COVID-19 compared with those without COPD. Our nationwide study showed that COVID-19 patients with COPD have higher symptomatic burden and more severe disease course than those without COPD.
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