Computed Tomography-Determined Body Composition Abnormalities Usefully Predict Long-term Mortality in Patients with Liver Cirrhosis
- Authors
- Cho, Young Seo; Lee, Ha Young; Jeong, Jae Yoon; Lee, Jae Gon; Kim, Tae Yeob; Nam, Seong Woo; Sohn, Joo Hyun
- Issue Date
- Oct-2021
- Publisher
- Lippincott Williams and Wilkins
- Keywords
- liver cirrhosis; body composition; computed tomography; prognosis
- Citation
- Journal of Computer Assisted Tomography, v.45, no.5, pp.684 - 690
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Computer Assisted Tomography
- Volume
- 45
- Number
- 5
- Start Page
- 684
- End Page
- 690
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140667
- DOI
- 10.1097/RCT.0000000000001207
- ISSN
- 0363-8715
- Abstract
- Objective We evaluated the prognostic impacts of body composition components measured by computed tomography (CT) in patients with liver cirrhosis. Methods A total of 160 cirrhotic patients who underwent CT and hepatic venous pressure gradient measurements were retrospectively enrolled. Cross-sectional areas of skeletal muscle, visceral and subcutaneous fat, and mean CT attenuation of trabecular bone of the fourth lumbar vertebral level (L4HU) were measured. Results Multivariate analysis showed model for end-stage liver disease score [hazard ratio (HR), 1.086; 95% confidence interval (CI), 1.020-1.156; P = 0.010], hepatic venous pressure gradient (HR, 1.076; 95% CI, 1.021-1.135; P = 0.006), sarcopenia (HR, 1.890; 95% CI, 1.032-3.462; P = 0.039), and L4HU (HR, 1.960 for L4HU <145 Hounsfield units; 95% CI, 1.094-3.512; P = 0.024) were independently associated with long-term mortality. In patients with decompensated cirrhosis, subcutaneous adipose tissue index was the only independent predictor (HR, 0.984; 95% CI, 0.969-0.999; P = 0.039). Conclusion Body composition abnormalities determined by CT are associated with long-term prognosis in cirrhotic patients.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.