기억력 손상 마우스에서 흑미 호분층 추출물의 인지능력 개선 효과

Abstract

Background: The aim of this study was to investigate the potential of black rice (Oryza sativa L.) aleurone layer (BR) extract at improving the memory function of scopolamine-induced memory impaired mice. Methods and Results: BR extract (150 and 300 ㎎/㎏), scopolamine (1 ㎎/㎏), and tacrine (10 ㎎/㎏) were administered to C57BL/6 mice. We analyzed the effects of BR extract on the scopol amine-induced cholinergic system, inflammatory response, and brain damage. It was observed that the BR extract offered protection against scopolamine-induced short- and long-term memory loss, and reduced learning deficits in the behavioral task. It also improved the cholinergic system and decreased the inflammatory cytokine levels. Furthermore, the BR extract downregulated the sco polamine-induced overexpression of amyloid β-peptide and caspase-3 in the hippocampus. Conclusions: These results suggest that the BR extract may be beneficial as a dietary supplement, due to its neuroprotective effect against cognitive impairment and cholinergic deficit