Experimental Demonstration of a Stacked Hybrid Optoacoustic-Piezoelectric Transducer for Localized Heating and Enhanced Cavitationopen access
- Authors
- Sang, Pil Gyu; Biswas, Deblina; Lee, Seung Jin; Won, Sang Min; Son, Donghee; Ok, Jong G.; Park, Hui Joon; Baac, Hyoung Won
- Issue Date
- Oct-2021
- Publisher
- MDPI
- Keywords
- laser-generated focused ultrasound; pulsed cavitation; tissue therapy; precision therapy
- Citation
- MICROMACHINES, v.12, no.10, pp.1 - 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- MICROMACHINES
- Volume
- 12
- Number
- 10
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140807
- DOI
- 10.3390/mi12101268
- Abstract
- Laser-generated focused ultrasound (LGFU) is an emerging modality for cavitation-based therapy. However, focal pressure amplitudes by LGFU alone to achieve pulsed cavitation are often lacking as a treatment depth increases. This requires a higher pressure from a transmitter surface and more laser energies that even approach to a damage threshold of transmitter. To mitigate the requirement for LGFU-induced cavitation, we propose LGFU configurations with a locally heated focal zone using an additional high-intensity focused ultrasound (HIFU) transmitter. After confirming heat-induced cavitation enhancement using two separate transmitters, we then developed a stacked hybrid optoacoustic-piezoelectric transmitter, which is a unique configuration made by coating an optoacoustic layer directly onto a piezoelectric substrate. This shared curvature design has great practical advantage without requiring the complex alignment of two focal zones. Moreover, this enabled the amplification of cavitation bubble density by 18.5-fold compared to the LGFU operation alone. Finally, the feasibility of tissue fragmentation was confirmed through a tissue-mimicking gel, using the combination of LGFU and HIFU (not via a stacked structure). We expect that the stacked transmitter can be effectively used for stronger and faster tissue fragmentation than the LGFU transmitter alone.
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