Development of a Paper-Based Viscometer for Blood Plasma Using Colorimetric Analysis
- Authors
- Kang, Hyunwoong; Jang, Ilhoon; Song, Simon; Bae, Sang-Cheol
- Issue Date
- Apr-2019
- Publisher
- AMER CHEMICAL SOC
- Citation
- ANALYTICAL CHEMISTRY, v.91, no.7, pp.4868 - 4875
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANALYTICAL CHEMISTRY
- Volume
- 91
- Number
- 7
- Start Page
- 4868
- End Page
- 4875
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/14273
- DOI
- 10.1021/acs.analchem.9b00624
- ISSN
- 0003-2700
- Abstract
- The viscosity of biofluids can be used to acquire meaningful medical information on the conditions of a patient but has seldom been utilized in clinical practices owing to cumbersome measurement procedures and the need for large sample volumes. We present a colorimetric method to measure the viscosity of blood plasma using a paper-based viscometer developed in this study specifically for clinical diagnosis. The proposed analytical device consists of multilayered papers with fluid-loading -mixing, and-measuring regions, and it can be fabricated readily in a simple manner using three-layered paper channels and tape. Moreover, the colorimetric analysis enables viscosity estimations by analyzing a single optical image. To validate the device performance, we measured the viscosities of fluids such as glycerin aqueous solutions, bovine-serum-albumin solution, dimethyl sulfoxide, and blood plasma. We found that the measured viscosities were in good agreement with the reference values. Finally, we developed a simple smartphone application for the viscosity measurements that helped enhance the convenience and utility of the paper-based viscometer while maintaining the measurement accuracy.
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