Systemic Delivery of Helical Polypeptide Induces Tumor-Specific Apoptosisopen access
- Authors
- Kasala, Dayananda; Lee, DaeYong; Lee, Soo-Hwan; Na, Youjin; Noh, Ilkoo; Ha, JongHoon; Yoo, Jisang; Bang, Hyun Bae; Park, Jong Hyun; Jeong, Ki Jun; Kim, Yeu-Chun; Yun, Chae-Ok
- Issue Date
- Apr-2019
- Publisher
- CELL PRESS
- Citation
- MOLECULAR THERAPY, v.27, no.4, pp.235 - 235
- Indexed
- SCIE
- Journal Title
- MOLECULAR THERAPY
- Volume
- 27
- Number
- 4
- Start Page
- 235
- End Page
- 235
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/14301
- ISSN
- 1525-0016
- Abstract
- A cationic helical peptide (CHP) has been intensively used as a gene or drug delivery carrier, and as antibiotics for therapeutic purposes in biomedical fields. CHPs are insufficient as delivery systems because they have a short chain length giving rise to a low helical propensity. In an effort to resolve these inherent limitations, artificial cationic helical polypeptides (ACHP) have been recently devised by further modifications of the side chains in functional group-bearing polypeptides. ACHP possess higher cell-penetrating property than conventional cell-penetrating peptides. However, these ACHP do not possess specificity toward diseases and penetrates into cells indiscriminately like their predecessors. To address these limitations,
we have added pH-sensitive anion-donating groups to a helical polypeptide enable the peptide to selectively penetrate into tumors through pH-dependent formational change of peptide following exposure to acidic tumor microenvironment. The mitochondriadestabilizing helical polypeptide undergoing pH-dependent conformational transitions led to efficient targeting of tumors and disruption of mitochondrial membranes, thus leading to tumorspecific induction of apoptosis. This work presents a promising peptide therapeutic system for cancer therapy.
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