Piceatannol inhibits effector T cell functions by suppressing TcR signaling
- Authors
- Kim, Do-Hyun; Lee, Yong-Gab; Park, Hong-Jai; Lee, Jung-Ah; Kim, Hyun Jung; Hwang, Jae-Kwan; Choi, Je-Min
- Issue Date
- Apr-2015
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Piceatannol; T cells; TcR signaling; T cell proliferation; T cell differentiation
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.25, no.2, pp.285 - 292
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 25
- Number
- 2
- Start Page
- 285
- End Page
- 292
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143556
- DOI
- 10.1016/j.intimp.2015.01.030
- ISSN
- 1567-5769
- Abstract
- Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of piceatannol has been extensively studied, its role in the adaptive immune response has received less attention. Here we investigated the role of piceatannol, a well-known Syk inhibitor, in T cell activation, proliferation, and differentiation using isolated murine splenic T cells from C57BL/6 mice. Piceatannol treatment inhibited surface expression of CD4 and CD8 T cell activation markers CD25 and CD69, reduced production of cytokines IFN gamma, IL-2, and IL-17, and suppressed proliferation of activated T cells. Moreover, piceatannol treatment significantly inhibited differentiation of CD4(+)CD25(-)CD62L(+) naive CD4 T cells into Th1, Th2, and Th17 cells, presumably due to inhibition of TcR signaling through p-Erk, p-Akt, and p-p38. Piceatannol appears to be a useful nutritional or pharmacological biomolecule that regulates effector T cell functions such as cytokine production, differentiation, and proliferation.
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