Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with gram-positive or gram-negative bacteriaopen access
- Authors
- Febus, Raymond; Lee, Sun-Kyung; Ahnn, Joohong
- Issue Date
- Nov-2014
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- calcineurin; calreticulin; innate immunity; calnexin
- Citation
- ANIMAL CELLS AND SYSTEMS, v.18, no.6, pp.394 - 398
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANIMAL CELLS AND SYSTEMS
- Volume
- 18
- Number
- 6
- Start Page
- 394
- End Page
- 398
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143972
- DOI
- 10.1080/19768354.2014.972981
- ISSN
- 1976-8354
- Abstract
- Innate immunity in Caenorhabditis elegans involves multiple processes including growth factor pathways, neuroendocrine signaling mediating various kinase activities. In this study, we report that calcineurin, a Ca2+/calmodulin-dependent serine/threonine phosphatase, regulates the nematode's vulnerability to bacterial pathogens. Interestingly, calcineurin seems to differently function in host-pathogen interaction of gram-positive and gram-negative bacteria. In addition, loss of calnexin, a Ca2+-binding chaperone in endoplasmic reticulum, compensates immune response of the nematode to gram-negative bacteria, while that of calreticulin has no effect. The results suggest that C. elegans has evolved different immune response strategy to gram-positive or gram-negative bacteria, utilizing the same immune machinery in different modes.
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