인후두 역류질환에서 양성자 펌프 억제제 치료가 삶의 질에 미치는 영향open accessImpact on Quality of Life after Treatment with Proton Pump Inhibitor in Laryngopharyngeal Reflux
- Other Titles
- Impact on Quality of Life after Treatment with Proton Pump Inhibitor in Laryngopharyngeal Reflux
- Authors
- 최해원; 전현웅; 정진혁; 김무건; 태경; 지용배
- Issue Date
- Nov-2020
- Publisher
- Korean Society of Otolaryngology
- Keywords
- Laryngopharyngeal reflux; Laryngoscopy; Proton pump inhibitor; Quality of life .
- Citation
- Korean Journal of Otorhinolaryngology Head and Neck Surgery, v.63, no.11, pp.517 - 522
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Otorhinolaryngology Head and Neck Surgery
- Volume
- 63
- Number
- 11
- Start Page
- 517
- End Page
- 522
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144368
- DOI
- 10.3342/kjorl-hns.2019.00899
- ISSN
- 2092-5859
- Abstract
- Background and Objectives
Several studies have assessed the impact of laryngopharyngeal reflux disease (LPRD) on the health-related quality of life (HR-QoL), showing significant impairment of HR-QoL. This study aims to assess the impact of proton pump inhibitor (PPI) treatment of LPRDs to enhance HR-QoL.
Subjects and Method
We prospectively collected data from LPRD patients from April 2017 to July 2019. Patients who have reflux symptom index (RSI) of ≥13 or reflux finding score (RFS) of ≥7 were enrolled in this study. We assessed HR-QoL using a questionnaire with EORTC QLQ-H&N35, -C30 on the first visit. Patients were treated with PPI (Ilaprazole 20 mg/day) on their visits at 4, 8, and 12 weeks. RSI and RFS were measured at each visit and HR-QoL was reevaluated on the last visit.
Results
Ninety-five patients completed the 3-months follow-up and were enrolled in this study. Female : male ratio was 71:24 and the mean age was 57.0±11.9 (27-80). The initial RSI and RFS were 16.3±8.8 and 12.6±2.9, respectively, but were changed to 11.1±9.7 and 9.7±2.6 (p<0.001 in both) at 12 weeks after the treatment. Global health status/QoL, speech problem, dry mouth, and coughing were significantly improved.
Conclusion
PPI administration is effective in treating LPRD, where effects begin to appear at 4 weeks after treatment. HR-QoL was also improved in patients who have RSI improvement.
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