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CD24 regulates stemness and the epithelial to mesenchymal transition through modulation of Notch1 mRNA stability by p38MAPK
- Authors
- Lim, Juyeon; Lee, Kyung-min; Shim, Jaekyung; Shin, Incheol
- Issue Date
- Sep-2014
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Breast cancer; CD24; CSC; EMT; Notch1
- Citation
- ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v.558, pp.120 - 126
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Volume
- 558
- Start Page
- 120
- End Page
- 126
- ISSN
- 0003-9861
- Abstract
- We report here that CD24 knockdown resulted in decreased expression of Notch1 in MCF-7 cells. CD24-downstream p38MAPK was shown to regulate Notch1 at the level of mRNA stability. We also found that CD24-mediated cell migration, invasion, mammosphere formation, and drug resistance was regulated by its downstream target Notch1. Together, our results indicate that CD24 may regulate the epithelial to mesenchymal transition and sternness through Notch1 signaling in breast cancer cells.
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Related Researcher
- Shin, In cheol
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)