Microfluidic Image Cytometry (mu FIC) Assessments of Silver Nanoparticle Cytotoxicity
- Authors
- Park, Jonghoon; Yoon, Tae Hyun
- Issue Date
- Dec-2012
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Microfluidic image cytometry; Microfluidic device; Cytotoxicity assessment; Ag nanoparticles; Nanotoxicity
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.12, pp.4023 - 4027
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 33
- Number
- 12
- Start Page
- 4023
- End Page
- 4027
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144690
- DOI
- 10.5012/bkcs.2012.33.12.4023
- ISSN
- 0253-2964
- Abstract
- Cytotoxicity assessment of silver nanoparticles (AgNPs) was performed using MTT-based microfluidic image cytometry (mu FIC). The LC50 value of HeLa cells exposed to AgNPs in the microfluidic device was estimated as 46.7 mg/L, which is similar to that estimated by MTT-based IC for cells cultured in a 96 well plate (49.9 mg/L). These results confirm that the mu FIC approach can produce cytotoxicity data that is reasonably well-matched with that of the conventional 96 well plate system with much higher efficiency. This mu FIC method provides many benefits including ease of use and low cost, and is a more rapid in vitro cell based assay for AgNPs. This may aid in speeding up data acquisition in the field of nanosafety and make a significant contribution to the quantitative understanding of nanoproperty- toxicity relationships.
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