Polarization-extinction-based detection of DNA hybridization in situ using a nanoparticle wire-grid polarizer
- Authors
- Yu, Hojeong; Oh, Youngjin; Kim, Soowon; Song, Seok Ho; Kim, Donghyun
- Issue Date
- Sep-2012
- Publisher
- OPTICAL SOC AMER
- Citation
- OPTICS LETTERS, v.37, no.18, pp.3867 - 3869
- Indexed
- SCIE
SCOPUS
- Journal Title
- OPTICS LETTERS
- Volume
- 37
- Number
- 18
- Start Page
- 3867
- End Page
- 3869
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144719
- DOI
- 10.1364/OL.37.003867
- ISSN
- 0146-9592
- Abstract
- Metallic wires can discriminate light polarization due to strong absorption of electric fields oscillating in parallel to wires. Here, we explore polarization-based biosensing of DNA hybridization in situ by employing metal target-conjugated nanoparticles to form a wire-grid polarizer (WGP) as complementary DNA strands hybridize. Experimental results using gold nanoparticles of 15 nm diameter to form a WGP of 400 nm period suggest that polarization extinction can detect DNA hybridization with a limit of detection in the range of 1 nM concentration. The sensitivity may be improved by more than an order of magnitude if larger nanoparticles are employed to define WGPs at a period between 400 and 500 nm.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 자연과학대학 > 서울 물리학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144719)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.